Penicillin was the first important commercial product produced by an aerobic, submerged fermentation.
Lactic Acid Production- Lactic acid is produced through fermentation process so, the fermenting broth is ultra-filtered properly for removing lactic acid presented in it.In some plants, membrane filtration is used for the recovery of Tetracycline from the waste streams. Generally, membrane filtration is used for both purifying & concentrating Tetracycline broth. Tetracycline is an antibiotic which is generally used for treating acne. Membrane filtration is not only used for purifying and concentrating antibiotics like Streptomycin & Neomycin but also used for removing their colors. Membrane filtration is considered to be the most effective process for concentrating large amount of Lysozyme that founds in egg whites. Lysozyme is a kind of enzyme which helps in fighting against bacteria.
The main usage of membrane filtration is to purify and concentrate the broth during the production of penicillin. The technique of membrane filtration is being utilized for the concentration of Bacitracin broth before drying as it reduces the operational cost & capital. The production of bovine somatotropin or injectable porcine consists of fermentation and several other membrane filtration steps for the effective purification and concentration of hormones.īacitracin is one of the antibiotics which is used in the livestock feed. Somatotropin (Porcine or Bovine Somatotropin) is a growth hormone which is given to livestock (commonly in the form of topical agent or injection) for their improvement and for enhancing animals' feed efficiencies internally. To concentrate the peptide streams, NF is being utilized. Concentration of plasma is also done to reduce the shipping cost because it is further processed in different locations. Further, the protein is also recovered from many other waste stream processes.Ĭoncentration and De-Mineralization of Blood PlasmaĪfter the removal of blood cells (commonly by centrifuge), plasma can be concentrated through membrane filtration method. Membrane filtration process easily & effectively removes bacteria and other impurities from protein. Through ultra-filtration technique, various types of amino acids can be processed with more uniformity even with the strong characteristic dissimilarities with each other. Membrane filtration is more effective method for the clarification and concentration of amino acids as compared to the traditional processes. Purification & Concentration of Amino Acids Membranes are also an ordinary part of the industrial enzyme production lines which concentrate the enzymes before the further downstream processing stages. Separation methods like centrifugation and rotary vacuum filters are successfully replaced by membrane filtration technique in various plants by improving product yields and decreasing the maintenance cost and involvement of the operators.
In any fermentation process, cell harvesting or biomass recovery is considered to be an important step specially when intermediates like antibiotics manufactured in bulk quantity.
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